Alanine aminopeptidase

Alanyl (membrane) aminopeptidase
Identifiers
Symbols ANPEP; APN; CD13; GP150; LAP1; P150; PEPN
External IDs OMIM151530 MGI96749 HomoloGene68163 GeneCards: ANPEP Gene
EC number 3.4.11.2
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 290 16790
Ensembl ENSG00000166825 ENSMUSG00000039062
UniProt P15144 Q3TB69
RefSeq (mRNA) NM_001150.2 NM_008486.2
RefSeq (protein) NP_001141.2 NP_032512.2
Location (UCSC) Chr 15:
90.33 – 90.36 Mb
Chr 7:
86.97 – 86.99 Mb
PubMed search [1] [2]

Alanine aminopeptidase (EC 3.4.11.2) is an enzyme that is used as a biomarker to detect damage to the kidneys, and that may be used to help diagnose certain kidney disorders. It is found at high levels in the urine when there are kidney problems.

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.[1]

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